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Home / Primary Antibodies

ZMYND8 Antibody

SKU : BHA10558058

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA251537
Alternative Names	CTCL tumor antigen se14-3; Cutaneous T-cell lymphoma associated antigen se14-3; KIAA1125; PKCB; PKCB1
Categories	Primary Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.Fossey S.C., Mamm. Genome 11:919-925(2000). Eichmueller S., Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).Deloukas P., Nature 414:865-871(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from inteal of Human PKCB1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. Fossey S.C., Mamm. Genome 11:919-925(2000). Eichmueller S., Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001). Deloukas P., Nature 414:865-871(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PKCB1 protein.
Subcellular Location	Nucleus

Antigen	ZMYND8
Uniprot	Q9ULU4
Database Links	HGNC:9397 KEGG:hsa:23613 UniGene:Hs.446240
Function	May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
Tissue Specificity	Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558058	CSB-PA251537	100ul	$297		Add to Cart

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