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YWHAB Antibody

SKU : BHA10558074

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA981536
Alternative Names	14-3-3 protein beta/alpha; 1433B; 143B; KCIP-1; Protein 1054
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.Leffers H., J. Mol. Biol. 231:982-998(1993).Deloukas P., Nature 414:865-871(2001).Gevaert K., Nat. Biotechnol. 21:566-569(2003).Chi A., J. Proteome Res. 5:3135-3144(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human 14-3-3 β.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Leffers H., J. Mol. Biol. 231:982-998(1993). Deloukas P., Nature 414:865-871(2001). Gevaert K., Nat. Biotechnol. 21:566-569(2003). Chi A., J. Proteome Res. 5:3135-3144(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total 14-3-3 β protein.
Subcellular Location	Cytoplasm, Melanosome

Uniprot	P31946
Database Links	HGNC:12849 OMIM:601289 KEGG:hsa:7529 STRING:9606.ENSP00000300161 UniGene:Hs.643544
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Pathway	Hippo signaling pathway PI3K-Akt signaling pathway Cell cycle
Protein Families	14-3-3 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558074	CSB-PA981536	100ul	$297		Add to Cart

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