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Home / Primary Antibodies

YAP1 Antibody (phospho-S127) (F48658)

SKU : BHA17101316

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NSJ Bioreagents

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Mfr.No.	F48658, F48658-0.08ML, F48658-0.4ML
Antigen	Phospho-YAP1
Clonality	Polyclonal
Description	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	This phospho-YAP antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS127 of human YAP1.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P46937

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the phospho-YAP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	DB, ELISA
Dilution	Dot blot: 1:500

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101316-1	F48658-0.08ML	0.08ml	$165		Add to Cart
BHA17101316-2	F48658-0.4ML	0.4ml	$379		Add to Cart

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