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Home / Antibodies

XRCC4 Antibody

SKU : BHA10557745

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA956465
Alternative Names	DNA-repair protein XRCC4; X-ray repair cross-complementing protein 4;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.Ling Chen, J. Biol. Chem., Aug 2000; 275: 26196. J篓顩
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human XRCC4.
Involvement In Disease	Short stature, microcephaly, and endocrine dysfunction (SSMED)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Ling Chen, J. Biol. Chem., Aug 2000; 275: 26196. J
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total XRCC4 protein.
Subcellular Location	Nucleus

Uniprot	Q13426
Database Links	HGNC:12831 OMIM:194363 KEGG:hsa:7518 STRING:9606.ENSP00000342011 UniGene:Hs.567359
Function	Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Protein Families	XRCC4 family
Tissue Specificity	Widely expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557745	CSB-PA956465	100ul	$297		Add to Cart

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