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Home / Antibodies

WWTR1 Antibody

SKU : BHA10557583

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA563551
Alternative Names	WWTR1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.Kanai F., Marignani P.A., Sarbassova D., Yagi R. EMBO J. 19:6778-6791(2000) Lei Q.Y., Zhang H., Zhao B., Zha Z.Y. Mol. Cell. Biol. 28:2426-2436(2008) Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R. Nat. Cell Biol. 10:837-848(2008) Di Palma T., D'Andrea B., Liguori G.L., Liguoro A. Exp. Cell Res. 315:162-175(2009)
Host	Rabbit
Immunogen	Peptide sequence around aa.386~390 (V-E-S-A-L) derived from Human TAZ.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Kanai F., Marignani P.A., Sarbassova D., Yagi R. EMBO J. 19:6778-6791(2000) Lei Q.Y., Zhang H., Zhao B., Zha Z.Y. Mol. Cell. Biol. 28:2426-2436(2008) Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R. Nat. Cell Biol. 10:837-848(2008) Di Palma T., D'Andrea B., Liguori G.L., Liguoro A. Exp. Cell Res. 315:162-175(2009)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total TAZ protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	Q9GZV5
Database Links	HGNC:24042 OMIM:607392 KEGG:hsa:25937 STRING:9606.ENSP00000353847 UniGene:Hs.477921
Function	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Pathway	Hippo signaling pathway
Tissue Specificity	Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557583	CSB-PA563551	100ul	$297		Add to Cart

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