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Home / Antibodies

WTAP Antibody

SKU : BHA10557924

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA722026
Alternative Names	KIAA0105; Putative pre-mRNA splicing regulator female-lethal (2D) homolog; WT1-associated protein; Wilms tumor 1-associating protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.Ortega A., J. Biol. Chem. 278:3040-3047(2003).Nagase T., DNA Res. 2:37-43(1995).Mungall A.J., Nature 425:805-811(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human WTAP.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. Ortega A., J. Biol. Chem. 278:3040-3047(2003). Nagase T., DNA Res. 2:37-43(1995). Mungall A.J., Nature 425:805-811(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total WTAPv protein.
Subcellular Location	Nucleus, nucleoplasm, Nucleus speckle

Uniprot	Q15007
Database Links	HGNC:16846 OMIM:605442 KEGG:hsa:9589 STRING:9606.ENSP00000351141 UniGene:Hs.446091
Function	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle
Protein Families	Fl(2)d family
Tissue Specificity	Ubiquitously expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557924	CSB-PA722026	100ul	$297		Add to Cart

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