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Home / Antibodies

WIPF1 Antibody

SKU : BHA10558764

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA031338
Alternative Names	WAS/WASL-interacting protein family member 1; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein; PRPL-2 protein; WIPF1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles By similarity. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.Ramesh N., Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997).Kreideweiss S., Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.Bechtel S., BMC Genomics 8:399-399(2007).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human WIPF1.
Involvement In Disease	Wiskott-Aldrich syndrome 2 (WAS2)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles By similarity. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. Ramesh N., Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997). Kreideweiss S., Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. Bechtel S., BMC Genomics 8:399-399(2007).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total WIPF1 protein.
Subcellular Location	Cytoplasmic vesicle, Cytoplasm, cytoskeleton, Cell projection, ruffle

Uniprot	O43516
Database Links	HGNC:12736 OMIM:602357 KEGG:hsa:7456 STRING:9606.ENSP00000352802 UniGene:Hs.128067
Function	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Pathway	Endocytosis
Protein Families	Verprolin family
Tissue Specificity	Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558764	CSB-PA031338	100ul	$297		Add to Cart

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