Mouse Anti-Human VPS35 Monoclonal IgG2b

Mfr.No.	SMC-606, SMC-606D, SMC-606D-A390, SMC-606D-A488, SMC-606D-A594, SMC-606D-ALP, SMC-606D-APC, SMC-606D-BI, SMC-606D-FITC, SMC-606D-HRP, SMC-606D-PCP, SMC-606D-RPE, SMC-606S
Immunogen Species	Human
Alternative Names	Vacuolar protein sorting-associated protein 35, MEM3, PARK17, VPS35 retromer complex component, maternal-embryonic 3, vesicle protein sortin 35, TCCCTA00141, FLJ10752
Antigen	VPS35
Categories	Antibodies
Cellular Localization	Vesicles, Endosome, Lysosome, Cytoplasm, Membrane
Certificate Of Analysis	A 1:1000 dilution of SMC-606 was sufficient for detection of VPS35 in 10 ug of SH-SY5Y by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Mouse Anti-Human VPS35 Monoclonal IgG2b
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen Region	Full length recombinant human VSP35
Isotype	IgG2b
Launch Date	2019/07/17
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Ubiquitous. Highly expressed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, testis, thymus.

Swissprot	Q96QK1
Accession Number	NP_060676.2
Gene Id	55737
Clone No	11H10
Research Area	Neuroscience \|Neurodegeneration, Membrane Trafficking Proteins, Cell Signaling, Parkinson's Disease, Golgi Proteins, Alzheimer's Disease, Protein Trafficking

Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration	1 mg/ml
Purification	Protein G Purified
Scientific Background	Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~92 kDa.
Storage	-20ÂºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, IP, IHC
Dilution	WB (1:1000); IP (1:200); IHC (1:100); optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162167 2. Zimprich, A. et al. (2011) Am J Hum Genet 89:168175 3. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11933343-1	SMC-606D	Unconjugated	100 ug	$387	Add to Cart
BHA11933343-2	SMC-606D-A390	ATTO 390	100 ug	$441	Add to Cart
BHA11933343-3	SMC-606D-A488	ATTO 488	100 ug	$440	Add to Cart
BHA11933343-4	SMC-606D-A594	ATTO 594	100 ug	$440	Add to Cart
BHA11933343-5	SMC-606D-ALP	Alkaline Phosphatase	100 ug	$433	Add to Cart
BHA11933343-6	SMC-606D-APC	APC	100 ug	$439	Add to Cart
BHA11933343-7	SMC-606D-BI	Biotin	100 ug	$436	Add to Cart
BHA11933343-8	SMC-606D-FITC	FITC	100 ug	$431	Add to Cart
BHA11933343-9	SMC-606D-HRP	HRP	100 ug	$427	Add to Cart
BHA11933343-10	SMC-606D-PCP	PerCP	100 ug	$439	Add to Cart
BHA11933343-11	SMC-606D-RPE	RPE	100 ug	$437	Add to Cart
BHA11933343-12	SMC-606S	Unconjugated	12 ug	$44	Add to Cart

VPS35 Antibody, Clone 11H10 - SMC-606