Von Willebrand Factor is a blood glycoprotein involved in hemostasis. The VWF gene encodes a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of platelet-vessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. vWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. Deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Mouse partial recombinant protein (AA 1304-1452) was used as the immunogen for this von Willebrand Factor antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Mouse, Rat
Recombinant
No
Gene Id
22371
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
The von Willebrand Factor antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaws.
Applications
WB, IHC-P
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml