VGF, also called NERP-2 (Neuroendocrine regulatory peptide-2), is a protein and neuropeptide that may play a role in regulating energy homeostasis, metabolism. Canu et al.(1997) noted that rat Vgf encodes a predicted 70-kD polypeptide that shares similarities with the secretogranin/chromogranin family and is found in the secretory granules of subsets of neurons and endocrine cells. By fluorescence in situ hybridization, Canu et al.(1997) assigned the VGF gene to 7q22. Canu et al.(1997) demonstrated that the single-copy human gene spans 6 kb of genomic DNA and contains 2 exons. The entire protein is encoded by exon 2, while exon 1 contains only 5-prime untranslated sequence. The structural organization of the human gene is similar to that described for the rat gene(Salton et al., 1991), and both the translated and the untranslated regions show a high degree of sequence homology to the rat gene.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human VGF (QARRAQEEAEAEERRLQEQ) was used as the immunogen for this VGF antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
O15240
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the VGF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.