JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies

VDR (Ab-51) Antibody

SKU : BHA10557686

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

CUSABIO TECHONOLOGY LLC

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	CSB-PA594723
Alternative Names	1,25-dihydroxyvitamin D3 receptor; NR1I1; vitamin D receptor; vitamin D3 receptor
Categories	Primary Antibodies
Clonality	polyclonal
Description	Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).Goto H., Biochim. Biophys. Acta 1132:103-108(1992).Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-S(p)-M-K).
Involvement In Disease	Rickets vitamin D-dependent 2A (VDDR2A)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988). Goto H., Biochim. Biophys. Acta 1132:103-108(1992). Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Vitamin D3 Receptor protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	P11473
Database Links	HGNC:12679 OMIM:277440 KEGG:hsa:7421 STRING:9606.ENSP00000447173 UniGene:Hs.524368
Function	Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Protein Families	Nuclear hormone receptor family, NR1 subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHA10557686	CSB-PA594723	100ul	$297		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.