Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.Ross M.T., Nature 434:325-337(2005).Ideguchi H., Biochem. J. 367:87-95(2002).Swanson D.A., Hum. Mol. Genet. 5:533-538(1996).
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human USP11.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.
Ross M.T., Nature 434:325-337(2005). Ideguchi H., Biochem. J. 367:87-95(2002). Swanson D.A., Hum. Mol. Genet. 5:533-538(1996).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total USP11 protein.