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Home / Primary Antibodies

UBASH3A Antibody

SKU : BHA10558711

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA785075
Alternative Names	Suppressor of T-cell receptor signaling 2; STS-2; Cbl-interacting protein 4; CLIP4; T-cell ubiquitin ligand
Categories	Primary Antibodies
Clonality	polyclonal
Description	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.Wattenhofer M., Hum. Genet. 108:140-147(2001).Feshchenko E.A., Oncogene 23:4690-4706(2004).Hattori M., Nature 405:311-319(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human UBASH3A.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. Wattenhofer M., Hum. Genet. 108:140-147(2001). Feshchenko E.A., Oncogene 23:4690-4706(2004). Hattori M., Nature 405:311-319(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total UBASH3A protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P57075
Database Links	HGNC:12462 OMIM:605736 KEGG:hsa:53347 STRING:9606.ENSP00000317327 UniGene:Hs.473912
Function	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Tissue Specificity	Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558711	CSB-PA785075	100ul	$297		Add to Cart

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