It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
SK-MEL-23 cells (clone TA99) and recombinant full-length human TYRP1 protein (clone TYRP1/807) were used as the immunogen for the TRP1 antibody cocktail.
Isotype
Mouse IgG2a, kappa+Mouse IgG2a, kappa
Species Reactivity
Human
Note
Optimal dilution of the TRP1 antibody should be determined by the researcher.
Uniprot
P17643
Format
Purified
Purity
Protein A/G affinity
Storage
Aliquot the TRP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.