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Home / Primary Antibodies

TrkA Antibody (NTRK1) (F50682)

SKU : BHA17101781

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Mfr.No.	F50682, F50682-0.08ML, F50682-0.4ML
Clonality	Polyclonal
Description	This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Alteate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Isoform 3 is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. (Isoform 3 information courtesy of UniProt).
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 654-683 from the human protein was used as the immunogen for this TrkA antibody.
Isotype	Ig
Predicted Reactivity	Human, Mouse
Reactivity	Human, Mouse
Recombinant	No

Uniprot	P04629

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Store at 4°C for up to one month. For long term, aliquot the TrkA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, FACS, ELISA
Dilution	Weste blot: 1:1000,Flow Cytometry: 1:10-1:50

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101781-1	F50682-0.08ML	0.08ml	$165		Add to Cart
BHA17101781-2	F50682-0.4ML	0.4ml	$379		Add to Cart

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