Translocation-Associating Membrane Protein 2, also called KIAA0057, is a protein that in humans is encoded by the TRAM2 gene. It is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum(ER) membrane. By genomic sequence analysis, Onuchic et al.(1999) mapped the gene to chromosome 6p21.1-p12 near the PKHD1 gene. Upon activation, quiescent hepatic stellate cells proliferate, change morphologically into myofibroblasts, and increase their synthesis of extracellular matrix proteins. Stefanovic et al.(2004) demonstrated that both TRAM2 and collagen type I are upregulated in activated rat and human hepatic stellate cells.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of mouse Translocation-Associating Membrane Protein 2 (RFIHSQLRHWREYWKEQ) was used as the immunogen for this TRAM2 antibody (100% rat homology).
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
Q924Z5
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the TRAM2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.