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Home / Primary Antibodies

TRAF4 Antibody

SKU : BHA10558838

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA788984
Alternative Names	TNF receptor-associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Malignant 62; RING finger protein 83; TRAF4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract By similarity. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.Tomasetto C.L., Genomics 28:367-376(1995).Miller H.G., Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.Cai C.L., Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TRAF4.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract By similarity. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Tomasetto C.L., Genomics 28:367-376(1995). Miller H.G., Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. Cai C.L., Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TRAF4 protein.
Subcellular Location	Cytoplasm, Nucleus, Cytoplasm, perinuclear region, Cell junction, tight junction, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton

Uniprot	Q9BUZ4
Database Links	HGNC:12034 OMIM:602464 KEGG:hsa:9618 STRING:9606.ENSP00000262395 UniGene:Hs.8375
Function	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
Pathway	IL-17 signaling pathway
Protein Families	TNF receptor-associated factor family, B subfamily
Tissue Specificity	Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558838	CSB-PA788984	100ul	$297		Add to Cart

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