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Home / Antibodies

TPH2 (Ab-19) Antibody

SKU : BHA10557712

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA272667
Alternative Names	Neuronal tryptophan hydroxylase; NTPH; Tryptophan 5- monooxygenase 2;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.Bader M., Science 299:76-76(2003).Gibbs R.A., Nature 440:346-351(2006).Pandey A., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human TPH2 around the phosphorylation site of serine 19 (G-FI-S(p)-L-D).
Involvement In Disease	Major depressive disorder (MDD); Attention deficit-hyperactivity disorder 7 (ADHD7)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. Bader M., Science 299:76-76(2003). Gibbs R.A., Nature 440:346-351(2006). Pandey A., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TPH2 protein.

Uniprot	Q8IWU9
Database Links	HGNC:20692 OMIM:607478 KEGG:hsa:121278 STRING:9606.ENSP00000329093 UniGene:Hs.736576
Protein Families	Biopterin-dependent aromatic amino acid hydroxylase family
Tissue Specificity	Brain specific.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557712	CSB-PA272667	100ul	$297		Add to Cart

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