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Home / Antibodies

TOP2A (Ab-1343) Antibody

SKU : BHA10559145

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA438319
Alternative Names	alpha isozyme; DNA topoisomerase II; DNA topoisomerase II-alpha; P11388-1; TOP-2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.Tsai-Pflugfelder M., Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181(1988).Wasserman R.A., Cancer Res. 53:3591-3596(1993).Lang A.J., Gene 221:255-266(1998).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human TOP2A around the phosphorylation site of threonine 1343 (E-K-T(p)-D-D).
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. Tsai-Pflugfelder M., Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181(1988). Wasserman R.A., Cancer Res. 53:3591-3596(1993). Lang A.J., Gene 221:255-266(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TOP2A protein.
Subcellular Location	Cytoplasm, Nucleus, nucleoplasm

Uniprot	P11388
Database Links	HGNC:11989 OMIM:126430 KEGG:hsa:7153 STRING:9606.ENSP00000411532 UniGene:Hs.156346
Function	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Protein Families	Type II topoisomerase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559145	CSB-PA438319	100ul	$297		Add to Cart

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