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Home / Primary Antibodies

TOP1MT Antibody / Topoisomerase I mitochondrial (V7463SAF)

SKU : BHA17126536

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NSJ Bioreagents

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Mfr.No.	V7463SAF-100UG
Clonality	Recombinant Rabbit Monoclonal
Description	DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Rabbit
Immunogen Region	Recombinant full-length human protein was used as the immunogen for the recombinant TOP1MT antibody.
Isotype	Rabbit IgG, kappa
Species Reactivity	Human
Note	The stated application concentrations are suggested starting points. Titration of the recombinant TOP1MT antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Uniprot	Q969P6

Format	Purified
Purity	Protein A affinity chromatography
Storage	Store the recombinant TOP1MT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/recombinant-top1mt-antibody-tpimt-2r-v7463" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126536	V7463SAF-100UG	100 ug	$499		Add to Cart

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