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Home / Primary Antibodies

TNFRSF1B Antibody

SKU : BHA10559279

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA949730
Alternative Names	Tumor necrosis factor receptor superfamily member 1B [Precursor]; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Smith C.A., Science 248:1019-1023(1990).Kohno T., Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990).Beltinger C.P., Genomics 35:94-100(1996).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human TNF Receptor II.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Smith C.A., Science 248:1019-1023(1990). Kohno T., Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990). Beltinger C.P., Genomics 35:94-100(1996).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TNF Receptor II protein.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted

Uniprot	P20333
Database Links	HGNC:11917 OMIM:191191 KEGG:hsa:7133 STRING:9606.ENSP00000365435 UniGene:Hs.256278
Function	Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Pathway	TNF signaling pathway Adipocytokine signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559279	CSB-PA949730	100ul	$297		Add to Cart

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