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Home / Primary Antibodies

TNFRSF10A Antibody

SKU : BHA10557746

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA199651
Alternative Names	Tumor necrosis factor receptor superfamily member 10A [Precursor]; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Pan G., Science 276:111-113(1997).The MGC Project Team, Genome Res. 14:2121-2127(2004).Chaudhary P.M., Immunity 7:821-830(1997).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human TR10A.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Pan G., Science 276:111-113(1997). The MGC Project Team, Genome Res. 14:2121-2127(2004). Chaudhary P.M., Immunity 7:821-830(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TR10A protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	O00220
Database Links	HGNC:11904 OMIM:603611 KEGG:hsa:8797 STRING:9606.ENSP00000221132 UniGene:Hs.213467
Function	Receptor for the cytotoxic ligand TNFSF10/TRAIL
Pathway	Apoptosis Necroptosis Natural killer cell mediated cytotoxicity
Tissue Specificity	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557746	CSB-PA199651	100ul	$297		Add to Cart

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