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TNFAIP1 Antibody

SKU : BHA10557913

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA094566
Alternative Names	B12; B61; EDP1; MGC2317; TNAP1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.Wolf F.W., J. Biol. Chem. 267:1317-1326(1992).The MGC Project Team, Genome Res. 14:2121-2127(2004).Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TNAP1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Wolf F.W., J. Biol. Chem. 267:1317-1326(1992). The MGC Project Team, Genome Res. 14:2121-2127(2004). Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TNAP1 protein.
Subcellular Location	Cytoplasm, Nucleus, Endosome

Uniprot	Q13829
Database Links	HGNC:11894 OMIM:191161 KEGG:hsa:7126 STRING:9606.ENSP00000226225 UniGene:Hs.76090
Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
Protein Families	BACURD family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557913	CSB-PA094566	100ul	$297		Add to Cart

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