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Home / Primary Antibodies

TNF alpha Antibody (V2901SAF)

SKU : BHA17124486

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NSJ Bioreagents

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Mfr.No.	V2901SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	This antibody neutralizes TNF alpha biological activities. It prevents TNF alpha induced apoptosis in Jurkat cells. It also neutralizes HurTNFamediated cytotoxicity of L929 cells and inhibits tumor growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Recombinant human protein was used as the immunogen for the TNF-alpha antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the TNF-alpha antibody should be determined by the researcher.

Uniprot	P01375

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the TNF-alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	Inhibition, Neutralization, FACS, IF
Description	Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Inhibits tumor growth (order BSA/sodium azide-free format),Neutralizes rTNF- mediated cytotoxicity (order BSA/sodium azide-free format),Protects mice against toxicity of rhTNF- (order BSA/sodium azide-free format)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17124486	V2901SAF-100UG	100 ug	$499		Add to Cart

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