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Home / Primary Antibodies

TLK1 Antibody

SKU : BHA10558880

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA178566
Alternative Names	kinase TLK1; PKU-beta; tousled-like kinase 1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.Yamakawa A., Gene 202:193-201(1997).Sillje H.H.W., EMBO J. 18:5691-5702(1999).Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TLK1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Yamakawa A., Gene 202:193-201(1997). Sillje H.H.W., EMBO J. 18:5691-5702(1999). Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TLK1 protein.
Subcellular Location	Nucleus

Uniprot	Q9UKI8
Database Links	HGNC:11841 OMIM:608438 KEGG:hsa:9874 STRING:9606.ENSP00000411099 UniGene:Hs.744917
Function	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Protein Families	Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity	Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558880	CSB-PA178566	100ul	$297		Add to Cart

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