In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.Morfin F., J. Infect. Dis. 182:290-293(2000) [PubMed: 10882609].Nagamine M., J. Clin. Microbiol. 38:2750-2752(2000) [PubMed: 10878078].Saijo M., Antiviral Res. 56:253-262(2002) [PubMed: 12406508].
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human KITH_HHV1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Morfin F., J. Infect. Dis. 182:290-293(2000) [PubMed: 10882609]. Nagamine M., J. Clin. Microbiol. 38:2750-2752(2000) [PubMed: 10878078]. Saijo M., Antiviral Res. 56:253-262(2002) [PubMed: 12406508].
Species
Human Herpesvirus 1 (Hhv-1) (Human Herpes Simplex Virus 1)
Specificity
The antibody detects endogenous levels of total KITH_HHV1 protein.
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Protein Families
Herpesviridae thymidine kinase family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.