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Home / Antibodies

TIM-3 Antibody / HAVCR2 (V8766SAF)

SKU : BHA17127775

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NSJ Bioreagents

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Mfr.No.	V8766SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A recombinant human partial protein (amino acids 22-202) was used as the immunogen for this TIM-3 antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the TIM-3 antibody should be determined by the researcher.

Uniprot	Q8TDQ0

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the TIM-3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/tim-3-antibody-tim3-2399-v8766" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127775	V8766SAF-100UG	100 ug	$499		Add to Cart

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