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Home / Primary Antibodies

TIM-3 Antibody / HAVCR2 (V8724SAF)

SKU : BHA17127735

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NSJ Bioreagents

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Mfr.No.	V8724SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cel tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 22-202 from the human protein was used as the immunogen for the TIM3 antibody.
Isotype	Mouse IgG2c, kappa
Species Reactivity	Human
Note	Optimal dilution of the TIM3 antibody should be determined by the researcher.

Uniprot	Q8TDQ0

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the TIM3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB, IHC-P
Description	Weste blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/tim3-antibody-tim3-4029-v8724" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127735	V8724SAF-100UG	100 ug	$499		Add to Cart

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