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Home / Antibodies

TIGIT Antibody / VSTM3 / VSIG9 (V7583)

SKU : BHA17116616

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NSJ Bioreagents

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Mfr.No.	V7583, V7583-20UG, V7583-100UG
Antigen	TIGIT
Clonality	Monoclonal
Description	TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Mouse
Immunogen Region	A recombinant human TIGIT protein fragment within amino acids 22-141 was used as the immunogen for the TIGIT antibody.
Isotype	IgG2c,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q495A1
Clone No	TIGIT/3017

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity chromatography
Storage	Store the TIGIT antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	ELISA, FACS, IHC-P
Dilution	ELISA (order BSA/sodium azide-free format for coating),Flow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17116616-1	V7583-20UG	20ug	$219		Add to Cart
BHA17116616-2	V7583-100UG	100ug	$499		Add to Cart

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