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Home / Antibodies

TIA-1 Antibody / T-Cell Intracellular Antigen-1 (V8438SAF)

SKU : BHA17127494

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NSJ Bioreagents

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Mfr.No.	V8438SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Amino acids 279-380 from the human protein were used as the immunogen for the TIA1 antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the TIA1 antibody should be determined by the researcher.

Uniprot	P31483

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the TIA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IF, WB
Description	Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml for 1 hr at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/tia1-antibody-tia1-1313-v8438" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127494	V8438SAF-100UG	100 ug	$499		Add to Cart

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