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Home / Primary Antibodies

Thyroxine 5-deiodinase Antibody / DIO3 (F55036)

SKU : BHA17103496

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Mfr.No.	F55036, F55036-0.08ML, F55036-0.4ML
Antigen	Thyroxine 5-deiodinase
Clonality	Polyclonal
Description	DIO3 / Thyroxine 5-deiodinase belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 250-278 from the human protein was used as the immunogen for the Thyroxine 5-deiodinase antibody.
Isotype	IgG
Predicted Reactivity	Human, Rat
Reactivity	Human, Rat
Recombinant	No
Subcellular Location	Cytoplasmic, cell membrane

Uniprot	P55073

Format	Purified
Purification	Antigen affinity purified
Storage	Aliquot the Thyroxine 5-deiodinase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, IHC-P
Dilution	Western blot: 1:1000-1:2000, IHC, Immunohistochemistry (FFPE): 1:50-1:100

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17103496-1	F55036-0.08ML	0.08ml	$165		Add to Cart
BHA17103496-2	F55036-0.4ML	0.4ml	$379		Add to Cart

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