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Home / Antibodies

Thyroid Peroxidase Antibody (V8557SAF)

SKU : BHA17127598

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NSJ Bioreagents

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Mfr.No.	V8557SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 685-804 from the human protein was used as the immunogen for the Thyroid Peroxidase antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Uniprot	P07202

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/thyroid-peroxidase-antibody-tpo-3700-v8557" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127598	V8557SAF-100UG	100 ug	$499		Add to Cart

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