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Home / Primary Antibodies

Thymidylate Synthase Antibody (V9092SAF)

SKU : BHA17127936

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NSJ Bioreagents

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Mfr.No.	V9092SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a teary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Recombinant human protein was used as the immunogen for this anti-Thymidylate Synthase antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	P04818

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the anti-Thymidylate Synthase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/anti-thymidylate-synthase-antibody-spm453-v9092" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127936	V9092SAF-100UG	100 ug	$499		Add to Cart

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