Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, it is encoded by the TXN gene. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin plays a central role in humans and is increasingly linked to medicine through their response to reactive oxygen species (ROS). In plants, thioredoxins regulate a spectrum of critical functions, ranging from photosynthesis to growth, flowering and the development and germination of seeds. It has also recently been found to play a role in cell-to-cell communication.Solubilization tags are used, especially for recombinant proteins expressed in chaperone-deficient species such as E. coli, to assist in the proper folding in proteins and keep them from precipitating. These include thioredoxin (TRX) and poly(NANP). (Wiki)
Formulation
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host
Mouse
Immunogen Region
A recombinant protein was used as the immunogen for this TRX antibody.
Isotype
Mouse lgG1
Species Reactivity
NA
Note
The stated application concentrations are suggested starting points. Titration of the TRX antibody may be required due to differences in protocols and secondary/substrate sensitivity.