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Home / Antibodies

TH (Ab-31) Antibody

SKU : BHA10557535

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA695636
Alternative Names	TYH; DYT14; DYT5b; TH;
Antigen	TH
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.Kumer, S.C. and Vrana, K.E. (1996) J Neurochem 67, 443-62. Bodeau-P
Host	Rabbit
Immunogen	Peptide sequence around aa.29~33(V-T-S-P-R)derived from Mouse Tyrosine Hydroxylase.
Involvement In Disease	Segawa syndrome autosomal recessive (ARSEGS)
Raised In	Rabbit
Reactivity	Mouse, Rat
Regulatory	RUO
Relevance	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels. Kumer, S.C. and Vrana, K.E. (1996) J Neurochem 67, 443-62. Bodeau-P
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Tyrosine Hydroxylase protein.

Uniprot	P07101
Database Links	HGNC:11782 OMIM:191290 KEGG:hsa:7054 STRING:9606.ENSP00000370571 UniGene:Hs.435609
Function	Plays an important role in the physiology of adrenergic neurons.
Protein Families	Biopterin-dependent aromatic amino acid hydroxylase family
Tissue Specificity	Mainly expressed in the brain and adrenal glands.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557535	CSB-PA695636	100ul	$297		Add to Cart

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