This antibody reacts with the C-terminus of TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. TGF-a is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A 17-amino acid peptide from the C-terminus of the rat protein was used as the immunogen for this TGF a antibody.
Isotype
Mouse IgG1, kappa
Species Reactivity
Human
Note
Optimal dilution of the antibody should be determined by the researcher.
Uniprot
P01135
Format
Purified
Purity
Protein G affinity chromatography
Storage
Store the TGF-a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).