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Home / Antibodies

TEAD3 Antibody

SKU : BHA10558799

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA904251
Alternative Names	Transcriptional enhancer factor TEF-5; TEA domain family member 3; TEAD-3; DTEF-1; TEAD3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.Jacquemin P., J. Biol. Chem. 272:12928-12937(1997).Mungall A.J., Nature 425:805-811(2003).Zhao B., Genes Dev. 22:1962-1971(2008).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TEAD3.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Jacquemin P., J. Biol. Chem. 272:12928-12937(1997). Mungall A.J., Nature 425:805-811(2003). Zhao B., Genes Dev. 22:1962-1971(2008).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TEAD3 protein.
Subcellular Location	Nucleus

Uniprot	Q99594
Database Links	HGNC:11716 OMIM:603170 KEGG:hsa:7005 STRING:9606.ENSP00000345772 UniGene:Hs.485205
Function	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Pathway	Hippo signaling pathway
Tissue Specificity	Preferentially expressed in the placenta.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558799	CSB-PA904251	100ul	$297		Add to Cart

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