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Home / Primary Antibodies

TCF7L1 Antibody

SKU : BHA10558731

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA737037
Alternative Names	Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3; TCF7L1; TCF3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis By similarity. Down-regulates NQO1, leading to increased mitomycin c resistance.Sagara N., Cancer Res. 60:5959-5962(2000).Hillier L.W., Nature 434:724-731(2005).Castrop J., Nucleic Acids Res. 20:611-611(1992).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TCF7L1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis By similarity. Down-regulates NQO1, leading to increased mitomycin c resistance. Sagara N., Cancer Res. 60:5959-5962(2000). Hillier L.W., Nature 434:724-731(2005). Castrop J., Nucleic Acids Res. 20:611-611(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TCF7L1 protein.
Subcellular Location	Nucleus

Uniprot	Q9HCS4
Database Links	HGNC:11640 OMIM:604652 KEGG:hsa:83439 STRING:9606.ENSP00000282111 UniGene:Hs.516297
Function	Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Pathway	Hippo signaling pathway Melanogenesis Wnt signaling pathway Adherens junction
Protein Families	TCF/LEF family
Tissue Specificity	Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558731	CSB-PA737037	100ul	$297		Add to Cart

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