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Home / Antibodies

TCF4/TCF12 Antibody

SKU : BHA10558730

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA090601
Alternative Names	Class A helix-loop-helix transcription factor ME2; ITF-2; ITF2; Immunoglobulin transcription factor 2; MITF-2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription By similarity. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.Corneliussen B., J. Virol. 65:6084-6093(1991).Breschel T.S., Hum. Mol. Genet. 6:1855-1863(1997).Amiel J., Am. J. Hum. Genet. 80:988-993(2007).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TCF4/12.
Involvement In Disease	Pitt-Hopkins syndrome (PTHS); Corneal dystrophy, Fuchs endothelial, 3 (FECD3)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription By similarity. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Corneliussen B., J. Virol. 65:6084-6093(1991). Breschel T.S., Hum. Mol. Genet. 6:1855-1863(1997). Amiel J., Am. J. Hum. Genet. 80:988-993(2007).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TCF4/12 protein.
Subcellular Location	Nucleus

Uniprot	P15884
Database Links	HGNC:11634 OMIM:602272 KEGG:hsa:6925 STRING:9606.ENSP00000346440 UniGene:Hs.605153
Function	Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Tissue Specificity	Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558730	CSB-PA090601	100ul	$297		Add to Cart

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