Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.Rao Y., Proc. Natl. Acad. Sci. U.S.A. 96:10212-10217(1999).Jorde L.B., Nat. Genet. 16:311-315(1997).Mann M., Cell 127:635-648(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human TBX3.
Involvement In Disease
Ulnar-mammary syndrome (UMS)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Rao Y., Proc. Natl. Acad. Sci. U.S.A. 96:10212-10217(1999). Jorde L.B., Nat. Genet. 16:311-315(1997). Mann M., Cell 127:635-648(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TBX3 protein.
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Pathway
Signaling pathways regulating pluripotency of stem cells
Tissue Specificity
Widely expressed.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.