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Home / Primary Antibodies

TBP Antibody

SKU : BHA10557822

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA276652
Alternative Names	TATA binding factor; TATA sequence-binding protein; TATA-box binding protein; TATA-box factor; TFIID
Categories	Primary Antibodies
Clonality	polyclonal
Description	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.Peterson M.G., Science 248:1625-1630(1990).Mungall A.J., Nature 425:805-811(2003).Gangloff Y.G., Mol. Cell. Biol. 21:5109-5121(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TBP.
Involvement In Disease	Spinocerebellar ataxia 17 (SCA17)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Peterson M.G., Science 248:1625-1630(1990). Mungall A.J., Nature 425:805-811(2003). Gangloff Y.G., Mol. Cell. Biol. 21:5109-5121(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TBP protein.
Subcellular Location	Nucleus

Uniprot	P20226
Database Links	HGNC:11588 OMIM:600075 KEGG:hsa:6908 STRING:9606.ENSP00000230354 UniGene:Hs.590872
Function	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID
Protein Families	TBP family
Tissue Specificity	Widely expressed, with levels highest in the testis and ovary.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557822	CSB-PA276652	100ul	$297		Add to Cart

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