Mouse Anti-Human Tau Monoclonal IgG1

Mfr.No.	SMC-608, SMC-608D, SMC-608D-A390, SMC-608D-A488, SMC-608D-A594, SMC-608D-ALP, SMC-608D-APC, SMC-608D-BI, SMC-608D-FITC, SMC-608D-HRP, SMC-608D-PCP, SMC-608D-RPE, SMC-608S
Immunogen Species	Human
Alternative Names	Tau Antibody, Neurofibrillary tangle protein Antibody, MAPTL Antibody, Microtubule-associated protein tau Antibody, MTBT1 Antibody, Paired helical filament-tau Antibody, TAU Antibody, PHF-tau Antibody, MAPT Antibody, AI413597 antibody, AW045860 antibody, DDPAC antibody, FLJ31424 antibody, FTDP 17 antibody, G protein beta1/gamma2 subunit interacting factor 1 antibody, MAPT antibody, MAPTL antibody, MGC134287 antibody, MGC138549 antibody, MGC156663 antibody, Microtubule associated protein tau antibody, Microtubule associated protein tau isoform 4 antibody, Microtubule-associated protein tau antibody, MSTD antibody, Mtapt antibody, MTBT1 antibody, MTBT2 antibody, Neurofibrillary tangle protein antibody, Paired helical filament tau antibody, Paired helical filament-tau antibody, PHF tau antibody, PHF-tau antibody, PPND antibody, PPP1R103 antibody, Protein phosphatase 1, regulatory subunit 103 antibody, pTau antibody, RNPTAU antibody, TAU antibody, TAU_HUMAN antibody, Tauopathy and respiratory failure, included antibody
Antigen	Tau
Categories	Antibodies
Cellular Localization	Cell membrane, Cytoskeleton, Growth cone, Peripheral membrane protein, Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytosol, Dendrite, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Plasma Membrane, Tubulin Complex
Certificate Of Analysis	A 1:1000 dilution of SMC-608 was sufficient for detection of Tau 2N4R P301S Fibril in 20 ug of Mouse Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Mouse Anti-Human Tau Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen Region	Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils
Isotype	IgG1
Launch Date	2019/10/04
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Expressed in neurons.

Swissprot	P10636
Accession Number	NP_005901.2
Gene Id	4137
Clone No	3D4
Research Area	Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton

Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration	1mg/mL
Purification	Protein G Purified
Scientific Background	Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects Multiple Bands. Antibody detects monomer and fibril under native conditions (dot blot).
Storage	-20ÂºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, DB, ICC/IF, ELISA
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146148 (1907) 3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497. 4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18. 5. Bugiani, O. et al. (1999). J Neuropathol Exp Neurol. 58(6):667-77.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11933367-1	SMC-608D	Unconjugated	100 ug	$393	Add to Cart
BHA11933367-2	SMC-608D-A390	ATTO 390	100 ug	$447	Add to Cart
BHA11933367-3	SMC-608D-A488	ATTO 488	100 ug	$446	Add to Cart
BHA11933367-4	SMC-608D-A594	ATTO 594	100 ug	$446	Add to Cart
BHA11933367-5	SMC-608D-ALP	Alkaline Phosphatase	100 ug	$439	Add to Cart
BHA11933367-6	SMC-608D-APC	APC	100 ug	$444	Add to Cart
BHA11933367-7	SMC-608D-BI	Biotin	100 ug	$441	Add to Cart
BHA11933367-8	SMC-608D-FITC	FITC	100 ug	$437	Add to Cart
BHA11933367-9	SMC-608D-HRP	HRP	100 ug	$432	Add to Cart
BHA11933367-10	SMC-608D-PCP	PerCP	100 ug	$444	Add to Cart
BHA11933367-11	SMC-608D-RPE	RPE	100 ug	$442	Add to Cart
BHA11933367-12	SMC-608S	Unconjugated	12 ug	$44	Add to Cart

Tau Antibody, Clone 3D4 - SMC-608

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