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Home / Antibodies

TAOK3 Antibody

SKU : BHA10558804

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA935138
Alternative Names	Serine/threonine-protein kinase TAO3; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).Tassi E., J. Biol. Chem. 274:33287-33295(1999).Zhang W., Biochem. Biophys. Res. Commun. 274:872-879(2000).Yustein J.T., Oncogene 22:6129-6141(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TAOK3.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Tassi E., J. Biol. Chem. 274:33287-33295(1999). Zhang W., Biochem. Biophys. Res. Commun. 274:872-879(2000). Yustein J.T., Oncogene 22:6129-6141(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TAOK3 protein.
Subcellular Location	Cytoplasm, Cell membrane, Peripheral membrane protein

Uniprot	Q9H2K8
Database Links	HGNC:18133 OMIM:616711 KEGG:hsa:51347 STRING:9606.ENSP00000376317 UniGene:Hs.644420
Function	Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Pathway	MAPK signaling pathway
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity	Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558804	CSB-PA935138	100ul	$297		Add to Cart

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