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Home / Primary Antibodies / Polyclonal Antibodies

TAK1 Antibody (pSer439) - SPC-1086

BHA11914364
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Swissprot O43318
Accession Number NP_663304
Gene Id 6885
Target TAK1 (pSer439)
Research Area Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Epigenetics and Nuclear Signaling, Nuclear Signaling Pathways, NFkB Pathway, Tyrosine Kinases, Receptor Tyrosine Kinases, Cancer, Cell Death, Necroptosis, Cardiovascular System, Atherosclerosis, Vascular Inflammation, Inflammatory Mediators, Immunology, Innate Immunity, TLR Signaling
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
Scientific Background TAK1 encoded by the gene MAP3K7, is a protein-serine/threonine kinase that is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-beta signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFkappaB activation and activation of the p38 MAPK pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. TAK1 is important for TGF-beta1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 67.196 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11914364-1 SPC-1086D Unconjugated 100 ul $331
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BHA11914364-2 SPC-1086D-A390 ATTO 390 100 ul $385
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BHA11914364-3 SPC-1086D-A488 ATTO 488 100 ul $384
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BHA11914364-4 SPC-1086D-A594 ATTO 594 100 ul $384
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BHA11914364-5 SPC-1086D-BI Biotin 100 ul $380
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BHA11914364-6 SPC-1086D-FITC FITC 100 ul $375
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