Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex."Ito H., Atsuzawa K., Sudo K., Di Stefano P. J. Neurochem. 107:61-72(2008) "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation."Tarpey P.S., Smith R., Pleasance E., et al. Nat. Genet. 41:535-543(2009)"
Host
Rabbit
Immunogen
Peptide sequence around aa.305~309(A-P-T-S-F) derived from Human Synaptophysin
Involvement In Disease
Mental retardation, X-linked 96 (MRX96)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex." Ito H., Atsuzawa K., Sudo K., Di Stefano P. J. Neurochem. 107:61-72(2008) "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation." Tarpey P.S., Smith R., Pleasance E., et al. Nat. Genet. 41:535-543(2009)"
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Synaptophysin protein.
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Protein Families
Synaptophysin/synaptobrevin family
Tissue Specificity
Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.