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Synpr Antibody

SKU : BHA10557532

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA187327
Alternative Names	Synpr
Categories	Primary Antibodies
Clonality	polyclonal
Description	Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. Valtorta, F. et al. (2004) Bioessays 26, 445-53. Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14. Bonanomi, D. et al. (2007) Biochem J 404, 525-34.
Host	Rabbit
Immunogen	Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2.
Raised In	Rabbit
Reactivity	Mouse, Rat
Regulatory	RUO
Relevance	Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. Valtorta, F. et al. (2004) Bioessays 26, 445-53. Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14. Bonanomi, D. et al. (2007) Biochem J 404, 525-34.
Species	Rattus Norvegicus (Rat)
Specificity	The antibody detects endogenous levels of total synaptophysin 2 protein.
Subcellular Location	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Multi-pass membrane protein, Cell junction, synapse, synaptosome

Uniprot	P22831
Database Links	KEGG:rno:66030 STRING:10116.ENSRNOP00000011307 UniGene:Rn.211986
Function	Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein.
Protein Families	Synaptophysin/synaptobrevin family
Tissue Specificity	Central nervous system.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557532	CSB-PA187327	100ul	$297		Add to Cart

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