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Home / Primary Antibodies / Monoclonal Antibodies

Synaptotagmin 7 Antibody, Clone S275-14 - SMC-424

BHA11903963
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+1 866.986.9598
Email
[email protected]
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Swissprot Q9R0N7
Accession Number NP_061271.1
Gene Id 54525
Target Synaptotagmin 7
Clone No S275-14
Research Area Cell Markers, Neuron Markers, Presynaptic Markers, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Synaptotagmins constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacylbackbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~45kDa. Does not cross-react with Synaptotagmin-6 (or others). Can identify other isoforms bands at ~65kD.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF
Description WB ; IHC ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Schengrund C.L., et al. (2002) J Biol Chem. 277: 32815.

2. Reichardt L.F., et al. (1981) J Cell Biol. 91:257.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11903963-1 SMC-424D Unconjugated 100 ug $330
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BHA11903963-2 SMC-424D-A390 ATTO 390 100 ug $384
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BHA11903963-3 SMC-424D-A488 ATTO 488 100 ug $383
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BHA11903963-4 SMC-424D-A594 ATTO 594 100 ug $383
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BHA11903963-5 SMC-424D-ALP Alkaline Phosphatase 100 ug $376
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BHA11903963-6 SMC-424D-APC APC 100 ug $382
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BHA11903963-7 SMC-424D-BI Biotin 100 ug $378
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BHA11903963-8 SMC-424D-FITC FITC 100 ug $374
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BHA11903963-9 SMC-424D-HRP HRP 100 ug $370
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BHA11903963-10 SMC-424D-PCP PerCP 100 ug $382
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BHA11903963-11 SMC-424D-RPE RPE 100 ug $380
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BHA11903963-12 SMC-424S Unconjugated 12 ug $44
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