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Home / Primary Antibodies

STRADA Antibody

SKU : BHA10557958

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA235298
Alternative Names	STE20-related adapter protein; STRAD alpha; Serologically defined breast cancer antigen NY-BR-96; STRAD; LYK5
Categories	Primary Antibodies
Clonality	polyclonal
Description	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.Scanlan M.J., Cancer Immun. 1:4-4(2001). Ota T., Nat. Genet. 36:40-45(2004). Baas A.F., EMBO J. 22:3062-3072(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human STRAD.
Involvement In Disease	A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Scanlan M.J., Cancer Immun. 1:4-4(2001). Ota T., Nat. Genet. 36:40-45(2004). Baas A.F., EMBO J. 22:3062-3072(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total STRAD protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	Q7RTN6
Database Links	HGNC:30172 OMIM:608626 KEGG:hsa:92335 STRING:9606.ENSP00000336655 UniGene:Hs.514402
Function	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Pathway	mTOR signaling pathway AMPK signaling
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557958	CSB-PA235298	100ul	$297		Add to Cart

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