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Home / Antibodies

STK10 Antibody

SKU : BHA10558873

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA889950
Alternative Names	kinase GEK2; LOK; Lymphocyte-oriented kinase; Serine/threonine protein kinase 10; STK10
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.Kuramochi S., Immunogenetics 49:369-375(1999).Ota T., Nat. Genet. 36:40-45(2004).Schmutz J., Nature 431:268-274(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human STK10.
Involvement In Disease	Testicular germ cell tumor (TGCT)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. Kuramochi S., Immunogenetics 49:369-375(1999). Ota T., Nat. Genet. 36:40-45(2004). Schmutz J., Nature 431:268-274(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total STK10 protein.
Subcellular Location	Cell membrane, Peripheral membrane protein

Uniprot	O94804
Database Links	HGNC:11388 OMIM:273300 KEGG:hsa:6793 STRING:9606.ENSP00000176763 UniGene:Hs.744005
Function	Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity	Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558873	CSB-PA889950	100ul	$297		Add to Cart

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