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Home / Primary Antibodies

STEAP3 Antibody

SKU : BHA10559329

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA235551
Alternative Names	Metalloreductase STEAP3; EC 1.16.1.-; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6
Categories	Primary Antibodies
Clonality	polyclonal
Description	Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.Passer B.J., Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003).Korkmaz C.G., Oncogene 24:4934-4945(2005).Steiner M.S., Cancer Res. 60:4419-4425(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human STEA3.
Involvement In Disease	Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. Passer B.J., Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003). Korkmaz C.G., Oncogene 24:4934-4945(2005). Steiner M.S., Cancer Res. 60:4419-4425(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total STEA3 protein.
Subcellular Location	Endosome membrane, Multi-pass membrane protein

Uniprot	Q658P3
Database Links	HGNC:24592 OMIM:609671 KEGG:hsa:55240 STRING:9606.ENSP00000376822 UniGene:Hs.647822
Function	Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
Pathway	p53 signaling pathway
Protein Families	STEAP family
Tissue Specificity	Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559329	CSB-PA235551	100ul	$297		Add to Cart

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